Severe ischemic bowel necrosis caused by terlipressin during treatment of hepatorenal syndrome
نویسندگان
چکیده
Terlipressin is a vasopressin analogue that is widely used in the treatment of hepatorenal syndrome or variceal bleeding. Because it acts mainly on splanchnic vessels, terlipressin has a lower incidence of severe ischemic complications than does vasopressin. However, it can still lead to serious complications such as myocardial infarction, skin necrosis, or bowel ischemia. Herein we report a case of severe ischemic bowel necrosis in a 46-year-old cirrhotic patient treated with terlipressin. Although the patient received bowel resection, death occurred due to ongoing hypotension and metabolic acidosis. Attention should be paid to patients complaining of abdominal pain during treatment with terlipressin.
منابع مشابه
Terlipressin-Induced Ischemic Skin Necrosis: A Rare Association
BACKGROUND Terlipressin is a synthetic vasopressin analogue that is used in the treatment of bleeding esophageal varices and hepatorenal syndrome in patients with cirrhosis. Serious ischemic adverse events, such as skin necrosis involving the extremities, scrotum, trunk, and abdominal skin, are rarely observed. In the literature to date, 20 cases that developed ischemic skin necrosis due to ter...
متن کاملBiliary pancreatitis secondary to stones from a gall bladder remnant.
Since its introduction in the early 1990s, terlipressin has revolutionized management of liver disease with a role in the treatment of variceal haemorrhage and hepatorenal syndrome. Terlipressin has proven to be safe, with a lower incidence of side-effects compared with vasopressin and other synthetic analogues. Although, terlipressin is selective for the spanchnic circulation, it can exert vas...
متن کاملTerlipressin and albumin for type 1 hepatorenal syndrome: does bacterial infection affect the response?
Vasoconstrictor therapy with terlipressin and concomitant albumin can improve renal function in patients with hepatorenal syndrome (HRS) type 1, but the efficacy of therapy in patients with active infection is controversial. The aim of this study was to investigate the efficacy, adverse effects, and predictors of terlipressin therapy and to find out whether there was a difference in response ra...
متن کاملTerlipressin for hepatorenal syndrome: A meta-analysis of randomized trials.
BACKGROUND Hepatorenal syndrome (HRS) is a severe complication of end-stage renal disease whose management still constitutes a big challenge. Various approaches have been used for hepatorenal syndrome treatment, including vasoconstrictor therapy. Terlipressin, a vasopressin analogue, has frequently been used. AIM To evaluate the efficacy and safety of terlipressin in patients with HRS by perf...
متن کاملMeta-analysis: terlipressin therapy for the hepatorenal syndrome.
BACKGROUND The hepatorenal syndrome is a severe and well-known complication of end-stage liver disease, but its management is controversial. Recent reports have shown the efficacy of terlipressin therapy, a vasopressin analogue, in hepatorenal syndrome patients. AIM To evaluate the efficacy and safety of terlipressin in the treatment of hepatorenal syndrome. METHODS We performed a systemati...
متن کامل